Colibactin-induced genotoxicity and colorectal cancer exacerbation critically depends on adhesin-mediated epithelial binding
M. Jans, M. Kolata, G. Blancke, M. Ciers, A. B. Dohlman, T. Kusakabe, M. Sze, A. Thiran, G. Berx, S. Tejpar, G. van Loo, I. D. Iliev, H. Remaut, L. Vereecke
This study shows that pks+ E. coli's ability to worsen colorectal cancer depends on adhesins that allow it to bind to host cells and produce the genotoxin colibactin.
bioRxiv · Aug 16, 2023 · PreprintCancer Biology