M. Khaled

Insulin Amyloid Morphology is Encoded in H-bonds and Electrostatics Interactions Ruling Protein Phase Separation

The paper investigates how anion-protein interactions influence insulin phase separation and amyloid formation through H-bonds and electrostatics, revealing alternative pathways to fibril formation.

Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane

This study uses molecular dynamics simulations to show that Aβ42 dimers form β-sheets in solution but not at neuronal membranes, with GM1 gangliosides inhibiting ordered oligomer formation.

Tumors escape immunosurveillance by overexpressing the proteasome activator REGγ

The paper shows cancer cells evade immunosurveillance by upregulating REGγ, which increases destruction of MHC-I peptides generated from nuclear translation products.