Author

A. Bachi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

L. Tronci· 2 shared A. Avgustinova· 1 shared A. Boletta· 1 shared A. Cattaneo· 1 shared A. Corrado· 1 shared A. D'Alessandro· 1 shared A. Esposito· 1 shared A. Gnocchi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

L. Tronci

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression

C. Podrini, S. Clerici, L. Tronci, D. Stefanoni, T. Canu, M. Chiaravalli, D. Spies, A. S. H. Costa, A. Esposito, A. D'Alessandro, C. Frezza, A. Bachi, A. Boletta

This study shows that inhibiting asparagine synthetase (ASNS) with antisense oligonucleotides reduces kidney volume and improves renal function in PKD mice by targeting metabolic pathways.

bioRxiv · Oct 10, 2023 · PreprintBiochemistry

FADS1/2-mediated lipid metabolic reprogramming drives ferroptosis sensitivity in triple-negative breast cancer

N. Lorito, A. Subbiani, A. Smiriglia, M. Bacci, F. Bonechi, L. Tronci, A. Corrado, D. L. Longo, M. Iozzo, L. Ippolito, G. Comito, E. Giannoni, I. Meattini, A. Avgustinova, P. Chiarugi, , A. Morandi

The paper identifies FADS1/2-mediated lipid metabolic reprogramming as a driver of ferroptosis sensitivity in triple-negative breast cancer, showing that high FADS1/2 expression correlates with poor prognosis and susceptibility to ferroptosis-inducing agents.

bioRxiv · Jun 30, 2023 · PreprintCancer Biology

Amyloid aggregates accumulate in melanoma metastasis driving YAP mediated tumor progression

V. Matafora, F. Farris, U. Restuccia, S. Tamburri, G. Martano, C. Bernardelli, F. Pisati, F. Casagrande, L. Lazzari, S. Marsoni, E. Bonoldi, A. Bachi

The paper shows amyloid aggregates accumulate in melanoma metastasis, driving YAP-mediated tumor progression through BACE regulation and mechanotransduction.

bioRxiv · Feb 10, 2020 · PreprintCancer Biology

ATR expands embryonic stem cell fate potential in response to replication stress

S. Atashpaz, S. Samadi Shams, J. M. Gonzalez, E. Sebestyen, N. Arghavanifard, A. Gnocchi, E. Albers, S. Minardi, G. Faga, P. Soffientini, E. Allievi, V. Cancila, A. Bachi, O. Fernandez-Capetillo, C. Tripodo, , V. Costanzo

This study identifies an ATR-CHK1 pathway in ESCs that enhances fate potential by inducing 2C-like gene expression in response to replication stress.

bioRxiv · Jan 1, 2020Cell Biology

Tumors escape immunosurveillance by overexpressing the proteasome activator REGγ

M. Boulpicante, R. Darrigrand, A. Pierson, V. Salgues, B. Gaudineau, M. Khaled, A. Cattaneo, A. Bachi, P. Cascio, S. Apcher

The paper shows cancer cells evade immunosurveillance by upregulating REGγ, which increases destruction of MHC-I peptides generated from nuclear translation products.

bioRxiv · Jan 6, 2019Immunology