Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence
V. Mallikarjun, O. Dobre, M. R. Jackson, M. Kidd, J. Llewellyn, H. T. Gilbert, S. M. Richardson, J. Swift
This study shows that loss of cytoskeletal proteostasis in senescent mesenchymal stem cells disrupts mechanotransduction and matrix protein secretion, linking cell size dysregulation to tissue maintenance issues.
bioRxiv · Oct 9, 2022 · PreprintCell Biology