J. Davis

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

Identifying mechanisms and therapeutic targets in muscle using Bayesian parameter estimation with conditional variational autoencoders

This paper uses a Conditional Variational Autoencoder to predict muscle twitch parameters from simulated and experimental data, identifying therapeutic targets for a cardiac mutation.

Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and conformational properties.

This study identifies how TREX1 preferentially degrades unprocessed HIV-1 DNA over 3-processed DNA through kinetic, thermodynamic, and structural differences.

Population level gene expression can repeatedly link genes to functions in maize

This study uses transcriptome-wide association studies in maize to identify flowering time genes, finding TWAS detects more genes than GWAS and links gene expression to function across tissues and environments.

Unique interactions and functions of the mitochondrial small Tims in Trypanosoma brucei

This study identifies unique interactions and functional roles of small TbTims in the TbTIM17 complex of T. brucei, revealing distinct complex architectures and dynamics.

Components of Isolated Skeletal Muscle Differentiated Through Antibody Validation

The paper describes a method to isolate skeletal muscle from mice, generate satellite cells for culture, and validate cell populations using immunofluorescence.

Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells

This paper describes a protocol for using proximity ligation assays (PLA) to study protein-protein interactions in mitochondria-endoplasmic reticulum contact sites (MERCs) in mouse skeletal muscle tissue and cells.

Creating Optimal Conditions for OPA1 isoforms by Western Blot in Muscle Tissue

This paper presents an optimized western blot protocol to isolate and detect five OPA1 isoforms in muscle tissue.

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue

This study uses 3D electron microscopy to analyze mitochondrial cristae morphology in mouse brown adipose tissue across aging, finding significant structural changes in aged tissue.

The oncogenic role of Streptococcus gallolyticus subsp. gallolyticus is linked to activation of multiple cancer-related signaling pathways

This study shows that SGG UCN34 promotes colon cancer by activating multiple cancer-related signaling pathways through proteomic and phosphoproteomic analyses in mice and human tumors.

Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle

This study investigates how Danicamtiv increases force and alters cardiac muscle contraction kinetics by modulating myosin function and cross bridge dynamics in cardiac tissue.

Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency

This study shows that targeting p38 in cardiac fibroblasts can reverse fibrosis and improve cardiomyocyte function in a mouse model of dilated cardiomyopathy.

Histone H1.0 Couples Cellular Mechanical Behaviors to Chromatin Structure

This study shows that histone H1.0 regulates cellular mechanical behaviors by controlling chromatin structure and gene expression in response to extracellular stress.

Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart

This study evaluates global cardiac function in mice with cardiac-restricted TRAF2 overexpression, finding diminished cardiac function despite reported tolerance to ischemic insults.

Charge neutralization of the active site glutamates does not limit substrate binding and transport by EmrE

The paper tests whether charge neutralization of glutamates limits EmrE's substrate binding and transport, finding it does not.

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

The Role of Mentoring in Promoting Diversity, Equity, and Inclusion in STEM Education and Research

The paper discusses the importance of mentoring in STEM for underrepresented minorities and presents workshop feedback showing student satisfaction despite low initial expectations.

An effective workshop on How to be an Effective Mentor for Underrepresented STEM Trainees

This workshop provides a framework for effective mentorship of underrepresented STEM trainees to address systemic issues in academic pipelines.

Using a Champion-Oriented Mindset to Overcome the Challenges of Graduate School

The paper describes a workshop aimed at preparing minority students for graduate school by fostering a champion-oriented mindset, showing it was well-received and perceived as helpful.

Multiple spillovers and onward transmission of SARS-Cov-2 in free-living and captive White-tailed deer

SARS-CoV-2 was detected in one-third of sampled white-tailed deer in Iowa between September 2020 and January of 2021 that likely resulted from multiple human-to-deer spillover and deer-to-deer transmission events.

Comprehensive antibody profiling of mRNA vaccination in children

This study compares humoral immune responses to mRNA vaccines in children aged 6-11 years, finding that a 100g dose elicits robust and dose-dependent cross-VOC antibody responses with preserved functional immunity.

Proteolytic Activation of Human-specific Olduvai Domains by the Furin Protease

The paper shows human-specific Olduvai domains are cleaved by furin protease, suggesting they function as proproteins activated by this processing, linking their expansion to human brain evolution.

Trypanosoma brucei Tim50 Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity

This study shows that TbTim50 is essential for mitochondrial function, kDNA replication, and cell cycle regulation in Trypanosoma brucei, and its depletion reduces parasite infectivity.

Of Rats and Men, a Translational Model to Understand Vancomycin Pharmacokinetic/Toxicodynamic relationships

The paper links vancomycin toxicity data from a rat model to two human clinical studies, showing rats are more sensitive to kidney injury at therapeutic concentrations.

Fibroblast State Reversal By MBNL1-Dependent Transcriptome Modification Regulates Cardiac Repair

This study shows that MBNL1 regulates fibroblast state transitions in cardiac repair, with overexpression preventing fibrosis and loss reverting cells to a progenitor state.

IBEX: A versatile multi-plex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues

IBEX enables high-resolution, multi-plex imaging of over 65 parameters in tissue sections without degradation, supporting spatial analysis and integration with other technologies.

A Single Dose of Self-Transcribing and Replicating RNA Based SARS-CoV-2 Vaccine Produces Protective Adaptive Immunity In Mice

A single dose of the STARR-based SARS-CoV-2 vaccine LUNAR-COV19 induces protective adaptive immunity in mice, including strong antibody and CD8+ T cell responses, and full protection against viral challenge.

Vimentin is Required for Tumor Progression and Metastasis in a Mouse Model of Non-Small Cell Lung Cancer

This study shows that vimentin is essential for metastasis in a mouse model of non-small cell lung cancer, as its loss impairs epithelial-to-mesenchymal transition and oxidative stress response.

Melatonin alters fluid phase co-existence in POPC/DPPC/cholesterol membranes

This study investigates how melatonin affects phase separation in ternary lipid membranes, suggesting a potential mechanism for its neuroprotective effects against amyloid-beta toxicity.

In vivo multi-dimensional information-keeping in Halobacterium salinarum

This paper demonstrates efficient in vivo DNA-encoded digital archives for 3D and 4D information storage using Halobacterium salinarum, with improved durability through mineral salt preservation.