Author

M. Klima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:virus· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

E. Boura· 2 shared A. Aspuru-Guzik· 1 shared A. Kundaje· 1 shared A. Nigam· 1 shared C. Gorgulla· 1 shared D. Chalupska· 1 shared D. Rejman· 1 shared E. Konkolova· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

E. Boura

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

A. Nigam, M. F. D. Hurley, F. Li, E. Konkolova, M. Klima, J. Trylcova, R. Pollice, S. S. Cınaroglu, R. Levin-Konigsberg, J. Handjaya, M. Schapira, I. Chau, S. Perveen, H.-L. Ng, H. U. Kaniskan, , A. Aspuru-Guzik

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

bioRxiv · Oct 3, 2023 · PreprintBiochemistry

The structure of monkeypox virus 2'-O-ribose methyltransferase VP39 in complex with sinefungin provides the foundation for inhibitor design

J. Silhan, M. Klima, D. Chalupska, J. Kozic, E. Boura

The paper determines the crystal structure of MPXV VP39 in complex with sinefungin, revealing conserved inhibitor binding that suggests broad antiviral potential.

bioRxiv · Sep 27, 2022 · PreprintMicrobiology

The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathione-β-synthase domain

Z. Knejzlik, M. Dolezal, K. Herkommerova, K. Clarova, M. Klima, M. Dedola, E. Zbornikova, D. Rejman, I. Pichova

The paper identifies the mycobacterial guaB1 gene as encoding a novel GMPR with CBS domains, showing its role in purine salvage and pH-dependent regulation.

bioRxiv · Aug 5, 2021 · PreprintBiochemistry