Author

J. Silhan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein structure prediction· 3 Organism:human· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

E. Boura· 5 shared D. Chalupska· 2 shared A. Huskova· 1 shared A. O Donoghue· 1 shared B. Cihlova· 1 shared B. Hurysz· 1 shared D. C. Dinesh· 1 shared J. Almaliti· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersBiophysics

E. Boura

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

J. Silhan, P. Fajtova, J. Bartosova, B. Hurysz, J. Almaliti, Y. Miyamoto, L. Eckmann, W. Gerwick, A. O Donoghue, E. Boura

This study determines the cryo-EM structures of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors, revealing their binding modes and explaining inhibitor specificity.

bioRxiv · Aug 17, 2023 · PreprintBiophysics

The structure of monkeypox virus 2'-O-ribose methyltransferase VP39 in complex with sinefungin provides the foundation for inhibitor design

J. Silhan, M. Klima, D. Chalupska, J. Kozic, E. Boura

The paper determines the crystal structure of MPXV VP39 in complex with sinefungin, revealing conserved inhibitor binding that suggests broad antiviral potential.

bioRxiv · Sep 27, 2022 · PreprintMicrobiology

Structural analysis of the OC43 coronavirus 2'-O-RNA methyltransferase

P. Dostalik, P. Krafcikova, J. Silhan, E. Boura

The paper reports the crystal structure of the OC43 coronavirus 2'-O-RNA methyltransferase complexed with sinefungin, revealing conserved SAM binding and structural differences that suggest antiviral target potential.

bioRxiv · Mar 16, 2021Biophysics

High-throughput fluorescent assay for inhibitor screening of proteases from RNA viruses

B. Cihlova, A. Huskova, J. Böserle, R. Nencka, E. Boura, J. Silhan

The paper develops a high-throughput fluorescent assay for screening protease inhibitors from RNA viruses and validates it for SARS-CoV-2 and tick-borne encephalitis virus.

bioRxiv · Oct 27, 2020Biochemistry

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

D. C. Dinesh, D. Chalupska, J. Silhan, V. Veverka, E. Boura

The paper determines the structure of the SARS-CoV-2 nucleocapsid phosphoprotein's N-terminal RNA binding domain and its interaction with RNA using NMR spectroscopy.

bioRxiv · Apr 2, 2020Biochemistry