Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis
L. Karra, D. Romero-Moya, O. Ksionda, M. Krush, Z. Gu, M. Mues, P. Depeille, C. Mullighan, J. Roose
This study shows that increased RASGRP1 signaling enhances stem cell fitness in native hematopoiesis but does not cause acute leukemia on its own.
bioRxiv · Jun 24, 2020Cancer Biology