Z. Gu

Two Separated Worlds: on the Preference of Influence in Life Science and Biomedical Research

This paper introduces a citation enrichment metric to analyze global scientific influence and finds two separated worlds of scientific exchange based on citation patterns.

Optimizing ex vivo CAR-T cell-mediated cytotoxicity assay through multimodality imaging

This study optimizes an ex vivo CAR-T cell-mediated cytotoxicity assay using multimodality imaging to improve real-time tracking and throughput.

Detection of High-Frequency Oscillations from Intracranial EEG Data with Switching State Space Model

This paper uses a Switching State Space Model to automatically detect high-frequency oscillations in intracranial EEG data, improving accuracy compared to manual annotation.

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

An Artificial Intelligence-Assisted Digital Microfluidic System for Multistate Droplet Control

This paper introduces an AI-assisted digital microfluidic system called DropAI for multistate droplet control using semantic segmentation and state machine feedback.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

PXN/Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling

This study shows that PXN phase separation drives focal adhesion assembly and integrin signaling through light-inducible manipulation.

A SI3-sigma; arch stabilizes cyanobacteria transcription initiation complex

The paper reports cryo-EM structures of cyanobacterial transcription initiation complexes and identifies an SI3-{sigma} arch that stabilizes the RNAP-promoter DNA open complex, essential for transcription initiation.

Modulating the selective utilization of carbon sources by engineering the 3rd and 4th helices of the DNA-binding domain of catabolite control protein A (CcpA) in Bacillus licheniformis

This study investigates how specific amino acids in the DNA-binding domain of CcpA affect carbon source utilization in Bacillus licheniformis through in vitro and in vivo experiments.

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

Reprogramming of stromal fibroblasts by chemotherapy-induced secretion of IFNβ1 drives re-growth of breast cancer cells after treatment.

This study shows chemotherapy-induced IFNβ1 secretion by cancer cells reprograms stromal fibroblasts, promoting breast cancer recurrence through an anti-viral state and pro-inflammatory cytokine expression.

Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

This study shows that increased RASGRP1 signaling enhances stem cell fitness in native hematopoiesis but does not cause acute leukemia on its own.

Structural Consequences of the Villin Headpiece Interaction with a Carbon Nitride Polyaniline (C3N) Nanosheet

This study uses molecular dynamics simulations to investigate how C3N nanosheets interact with the villin headpiece protein, revealing partial denaturation and unfolding mechanisms.

Membrane Insertion of MoS2 Nanosheets: Fresh vs. Aged

This study compares the interaction of fresh and aged MoS2 nanosheets with lipid membranes, finding that fresh nanosheets have stronger binding affinity.

Endoplasmic Reticulum Associated Degradation (ERAD) Deficiency Promotes Mitochondrial Dysfunction and Transcriptional Rewiring in Human Hepatic Cells

This study shows that ERAD deficiency causes mitochondrial dysfunction and transcriptional changes in human hepatic cells, linking ERAD to mitochondrial health.

Computational fluid dynamics simulation of changes in the morphology and airflow dynamics of the upper airways in OSAHS patients after treatment with oral appliances

This study uses CFD simulations to analyze how oral appliances alter upper airway morphology and airflow dynamics in OSAHS patients, showing reduced resistance and improved patency.

Nanoporous Boron Nitride for High Efficient Water Desalination

This study uses Molecular Dynamics simulations to show nanoporous boron nitride has higher water permeability and salt rejection than existing materials and graphene.

CRISPR/Cas9 screens Reveal Dasatinib Targets of Inhibiting T cell Activation and Proliferation

This study identifies dasatinib targets in T cell activation and proliferation using CRISPR/Cas9 screening in Jurkat cells, revealing both known and novel targets and their functional roles.

A negative feedback mechanism in the insulin-regulated glucose homeostasis in Japanese flounder Paralichthys olivaceus by two ways of glucose administration

This study compares glucose administration methods in Japanese flounder, showing different insulin and brain-gut peptide responses, and suggests a negative feedback mechanism in glucose homeostasis.