C. Mullighan

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1

The paper identifies a convergent malignant phenotype in infant B-ALL linked to SRRM1 upregulation and splicing alterations, independent of gene fusions.

Somatic mutations in CTCF zinc fingers produce cellular phenotypes explained by structure-function relationships

This study identifies somatic CTCF mutations in cancer and shows how their structure-function relationships affect cellular phenotypes and tumour suppressor function.

Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

This study shows that increased RASGRP1 signaling enhances stem cell fitness in native hematopoiesis but does not cause acute leukemia on its own.

Heme-Sensing Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

The paper identifies the heme-sensing pathway as a regulator of MCL-1 expression in B-lineage acute leukemia, showing that modulating this pathway enhances sensitivity to BH3-mimetics.