Cancer BiologybioRxivPreprint
Targeting Integrated Stress Response by ISRIB combined with imatinib attenuates STAT5 signaling and eradicates therapy-resistant Chronic Myeloid Leukemia cells
W. Dudka, G. Hoser, S. S. Mondal…·K. Piwocka
This study shows that combining ISRIB with imatinib reduces STAT5 signaling and eliminates imatinib-resistant CML cells by altering transcriptomic profiles.
DOI 10.1101/2021.05.05.442756