Cell BiologybioRxiv
D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability
G. Rona, B. Miwatani-Minter, Q. Zhang…·M. Pagano
This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.
DOI 10.1016/j.molcel.2024.02.010