Author

D. Simoneschi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Pagano· 3 shared E. Lane· 2 shared G. Rona· 2 shared M. A. Kerzhnerman· 2 shared Q. Zhang· 2 shared S. Keegan· 2 shared A. A. Wang· 1 shared A. M. Cuervo· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

M. Pagano

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

N. Garcia-Vazquez, T. J. Gonzalez-Robles, E. Lane, D. Spasskaya, Q. Zhang, M. A. Kerzhnerman, Y. Jeong, M. Collu, D. Simoneschi, K. V. Ruggles, G. Rona, S. Kaisari, M. Pagano

The paper shows cyclin D1-CDK4/6 stabilizes GTSE1, promoting cell proliferation and poor cancer prognosis.

bioRxiv · Jun 26, 2024 · PreprintBiochemistry

D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability

G. Rona, B. Miwatani-Minter, Q. Zhang, H. V. Goldberg, M. A. Kerzhnerman, J. B. Howard, D. Simoneschi, E. Lane, J. W. Hobbs, E. Sassani, A. A. Wang, S. Keegan, D. J. Laverty, C. G. Piett, L. S. Pongor, , M. Pagano

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

bioRxiv · Jan 12, 2024Cell Biology

The ULK1-FBXW5-SEC23B nexus controls autophagy

M. Pagano, Y.-T. Jeong, D. Simoneschi, S. Keegan, D. Melville, N. Adler, A. Saraf, L. Florens, M. P. Washburn, C. Cavasotto, D. Fenyö, A. M. Cuervo, M. Rossi

This study identifies the ULK1-FBXW5-SEC23B pathway as a regulator of autophagy by controlling COPII localization and SEC23B stability during nutrient starvation.

bioRxiv · Oct 12, 2018Cell Biology