M. Leda

Testing models of cell cortex wave generation by Rho GTPases

This study tests two theoretical models of Rho GTPase wave generation by simultaneously imaging total and active RhoA in cortical waves.

A versatile pattern-forming cortical circuit based on Rho, F-actin, Ect2 and RGA-3/4

The paper identifies Ect2 and RGA-3/4 as core components of a cortical excitability circuit and demonstrates the immature Xenopus oocyte as a model for studying excitable dynamics.

Cell cycle and developmental control of cortical excitability in Xenopus laevis

This study quantifies the onset and changes in cortical excitability in Xenopus laevis eggs and embryos, linking wave properties to cell cycle progression and cell size.

Rho and F-actin self-organize within an artificial cell cortex

This study creates an artificial cell cortex using Xenopus egg extract and lipid bilayers to observe self-organizing Rho and F-actin dynamics similar to those in vivo.

Autoamplification and competition drive symmetry breaking: Initiation of centriole duplication by the PLK4-STIL network

The paper proposes a biophysical model explaining how the PLK4-STIL network initiates centriole duplication through autoamplification and competition, leading to symmetry breaking.

Fission yeast NDR/LATS kinase Orb6 regulates exocytosis via phosphorylation of exocyst complex

This study identifies Orb6 as a kinase that regulates exocytosis by phosphorylating exocyst complex components Sec3 and Sec5, essential for polarized growth in fission yeast.

Local and global Cdc42 GEFs for fission yeast cell polarity are coordinated by microtubules and the Tea1/Tea4/Pom1 axis

This study shows that microtubules and the Tea1/Tea4/Pom1 axis coordinate local and global Cdc42 GEFs in fission yeast to maintain polarized growth.