C. Spanos

Multi-omic analyses reveal a differential contribution of chromatin-associated PP1 holoenzymes to mitotic exit and G1 re-establishment.

The paper investigates the role of three chromatin-associated PP1 targeting subunits in mitotic exit and G1 re-establishment using multi-omic analyses.

Molecular basis for condensin enrichment at pericentromeres

This study identifies a molecular mechanism by which condensin is recruited to pericentromeres through a conserved interaction between Ycg1 and Sgo1, ensuring proper chromosome segregation.

Checkpoint-independent association of Mad3BUBR1 with Stu1CLASP directs homolog alignment in meiosis I

This study identifies a checkpoint-independent role for Mad3BUBR1 in promoting homolog alignment during meiosis I through its interaction with Stu1CLASP.

Roles of SNORD115 and SNORD116 ncRNA clusters in neuronal differentiation

This study investigates the roles of SNORD115 and SNORD116 ncRNA clusters in neuronal differentiation and their potential link to Prader-Willi syndrome.

Rewiring of the phosphoproteome executes two meiotic divisions

The paper identifies how Spo13Meikin rewires the phosphoproteome through kinase activity to drive two meiotic divisions in budding yeast.

Direct recruitment of Mis18 to interphase spindle poles promotes CENP-A chromatin assembly

The paper shows that Mis18 directly binds to SPB components to recruit Mis18C, promoting CENP-A chromatin assembly independently of centromeres.

Ki-67 is necessary during DNA replication for forks protection and genome stability

This study shows Ki-67 is necessary for DNA replication, genome stability, and prevents DNA damage and interferon response when depleted.

mps1 and mad mutations reduce Cryptococcus neoformans titan cell viability

This study shows that mutations in mps1 and mad genes reduce viability of Cryptococcus neoformans titan cells during reductive division.

SUMOylation regulates Lem2 function in centromere clustering and silencing

The paper shows that SUMOylation of Lem2 in fission yeast affects centromere clustering and silencing by modulating its interactions with partner proteins.

Bub1 kinase acts as a signalling hub for the entire Cryptococcus neoformans spindle assembly checkpoint pathway

This study identifies CnBub1 as a multifunctional protein in Cryptococcus neoformans that integrates both Bub1 and Mad3/BubR1 functions in the spindle assembly checkpoint.

Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

This study shows hypoxia suppresses type I interferon signaling in ALI, leading to monocytopenia and unchecked inflammation, which can be mitigated by CSF1 administration.

Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance

The paper shows that proteasome-dependent truncation of Epe1 mediates antifungal resistance in fission yeast by altering H3K9 methylation and gene expression.

The phospho-docking protein 14-3-3 regulates microtubule-associated proteins in oocytes including the chromosomal passenger Borealin

This study identifies microtubule-associated proteins regulated by 14-3-3 in Drosophila oocytes, showing its role in Borealin localization and function through phosphorylation-dependent binding.

Mapping the invisible chromatin transactions of prophase chromosome remodelling

The paper maps early chromatin transactions during mitotic entry in chicken cells using proteomics and imaging, revealing dynamic changes in chromatin associations and protein dynamics.

A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

This study shows that mutations in the lncRNA RMRP impair pre-rRNA processing and T cell activation, linking CHH to a ribosomopathy.

CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

This study shows CDK4/6 inhibitors cause long-term cell cycle withdrawal by inducing replication stress and p53-dependent effects, linking them to genotoxic stress and potential combination therapies.

Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression.

This study identifies non-redundant roles of H2A.Z.1 and H2A.Z.2 in cell cycle regulation and chromosome segregation in human cells.

Integrative Vectors for Regulated Expression of SARS-CoV-2 Proteins Implicated in RNA Metabolism

The paper develops and characterizes expression constructs for 14 SARS-CoV-2 proteins involved in RNA metabolism, enabling their study in host cells.

The proteomic landscape of centromeric chromatin reveals an essential role for the Ctf19CCAN complex in meiotic kinetochore assembly

The paper uses proteomics to identify meiosis-specific kinetochore remodelling and reveals the essential role of the Ctf19cCCAN complex in meiotic kinetochore assembly.

Stress-induced translation inhibition through rapid displacement of scanning initiation factors

The paper shows stress-induced translation inhibition in yeast through rapid displacement of scanning initiation factors and selective mRNA degradation.

The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment

This study identifies the molecular interaction between BubR1 and CENP-E required for CENP-E recruitment to kinetochores and chromosome alignment during mitosis.

Defining the RNA Interactome by Total RNA-Associated Protein Purification

This paper introduces TRAPP, a method to identify RNA-binding proteins genome-wide, and demonstrates its application in yeast and bacteria, revealing novel RNA-protein interactions and their changes under stress.

Fission yeast NDR/LATS kinase Orb6 regulates exocytosis via phosphorylation of exocyst complex

This study identifies Orb6 as a kinase that regulates exocytosis by phosphorylating exocyst complex components Sec3 and Sec5, essential for polarized growth in fission yeast.

Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

The paper identifies how Mto1 docks at nuclear pore complexes via Crm1 and Nup146 to form non-centrosomal MTOCs.