Author

A. B. Goryachev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 7 Approach:experimental assay· 6 Organism:Xenopus· 4 Assay:imaging· 3 Approach:biophysical modeling· 2 Research Focus:development & morphogenesis· 2 Approach:statistical model· 2 Organism:zebrafish· 2

Frequent Co-Authors

M. Leda· 5 shared A. Michaud· 3 shared I. S. Erofeev· 3 shared J. Landino· 3 shared A. L. Miller· 2 shared A. P. van Loon· 2 shared A. Sagasti· 2 shared W. M. Bement· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersCell Biology

M. Leda

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Author profile →

8 papers

Recent·Most cited

A versatile pattern-forming cortical circuit based on Rho, F-actin, Ect2 and RGA-3/4

A. Michaud, M. Leda, Z. T. Swider, S. Kim, J. He, J. Landino, J. R. Valley, J. Huisken, A. B. Goryachev, G. von Dassow, W. Bement

The paper identifies Ect2 and RGA-3/4 as core components of a cortical excitability circuit and demonstrates the immature Xenopus oocyte as a model for studying excitable dynamics.

bioRxiv · Mar 8, 2022Cell Biology

Cell cycle and developmental control of cortical excitability in Xenopus laevis

Z. T. Swider, A. Michaud, M. Leda, J. Landino, A. B. Goryachev, W. M. Bement

This study quantifies the onset and changes in cortical excitability in Xenopus laevis eggs and embryos, linking wave properties to cell cycle progression and cell size.

bioRxiv · Feb 11, 2022 · PreprintCell Biology

Mechanosensitive calcium signaling promotes epithelial tight junction remodeling by activating RhoA

S. Varadarajan, R. E. Stephenson, E. R. Misterovich, J. L. Wu, I. S. Erofeev, A. B. Goryachev, A. L. Miller

The paper shows that mechanosensitive calcium flashes trigger RhoA activation, leading to tight junction remodeling in response to mechanical stress in Xenopus laevis epithelial cells.

bioRxiv · May 18, 2021Cell Biology

Rho and F-actin self-organize within an artificial cell cortex

J. Landino, M. Leda, A. Michaud, Z. Swider, M. Prom, C. M. Field, W. M. Bement, A. G. Vecchiarelli, A. B. Goryachev, A. L. Miller

This study creates an artificial cell cortex using Xenopus egg extract and lipid bilayers to observe self-organizing Rho and F-actin dynamics similar to those in vivo.

bioRxiv · Apr 9, 2021Cell Biology

Cortical myosin minifilaments orchestrate the arrangement of microridge protrusions on epithelial cell surfaces

A. P. van Loon, I. S. Erofeev, A. B. Goryachev, A. Sagasti

The paper investigates how cortical myosin II minifilaments drive microridge fission and fusion in zebrafish larvae, leading to ordered arrangement of these protrusions.

bioRxiv · Oct 22, 2020Cell Biology

Cortical contraction drives the 3D patterning of epithelial cell surfaces

A. P. van Loon, I. S. Erofeev, I. V. Maryshev, A. B. Goryachev, A. Sagasti

The paper shows how cortical contractions drive the formation of microridges on zebrafish skin cells by reducing membrane tension and promoting precursor fusion.

bioRxiv · Oct 25, 2019Cell Biology

Autoamplification and competition drive symmetry breaking: Initiation of centriole duplication by the PLK4-STIL network

M. Leda, A. J. Holland, A. B. Goryachev

The paper proposes a biophysical model explaining how the PLK4-STIL network initiates centriole duplication through autoamplification and competition, leading to symmetry breaking.

bioRxiv · Sep 29, 2018Cell Biology

Local and global Cdc42 GEFs for fission yeast cell polarity are coordinated by microtubules and the Tea1/Tea4/Pom1 axis

Y. D. Tay, M. Leda, A. B. Goryachev, K. E. Sawin

This study shows that microtubules and the Tea1/Tea4/Pom1 axis coordinate local and global Cdc42 GEFs in fission yeast to maintain polarized growth.

bioRxiv · Oct 31, 2017Cell Biology