Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors
Z. Xiao, L. Tood, L. Huang, E. Noguera-Ortega, Z. Lu, L. Huang, M. Kopp, Y. Li, N. B. Pattada, W. Zhong, W. Guo, J. Schollor, M. Liousia, C.-A. Assenmacher, C. H. June, , E. Pure
This study shows that targeting FAP+CAFs in desmoplastic pancreatic tumors reduces stromal barriers, enhances T cell infiltration, and improves response to immunotherapy.
bioRxiv · Apr 13, 2023Immunology