M. Kopp

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

This study shows that targeting FAP+CAFs in desmoplastic pancreatic tumors reduces stromal barriers, enhances T cell infiltration, and improves response to immunotherapy.

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

Evolutionary dynamics of sex-biased gene expression in a young XY system: Insightsfrom the brown alga genus Fucus

This study examines sex-biased gene expression in two dioecious brown algae species, finding conserved male-biased genes related to gamete production and accelerated evolution in male-biased genes.

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction

This study shows the D614G mutation in SARS-CoV-2 spike protein increases furin cleavage efficiency and alters RBD dynamics through allosteric effects.

Cold sensitivity of the SARS-CoV-2 spike ectodomain

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

The paper shows that HIV-1 broadly neutralizing antibodies recognize a glycan cluster on the SARS-CoV-2 spike protein, revealing a potential target for vaccine design.

Glycans on the SARS-CoV-2 Spike Control the Receptor Binding Domain Conformation

The paper shows glycans on SARS-CoV-2 Spike influence RBD conformational states, affecting antibody neutralization and vaccine design.

The seagrass methylome memorizes heat stress and is associated with variation in stress performance among clonal shoots

This study shows that clonal seagrass shoots have DNA methylation variation linked to photosynthetic performance and heat stress resilience, suggesting epigenetic variation complements genetic diversity in stress adaptation.

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation

The paper analyzes SARS-CoV-2 spike protein conformations and develops engineered constructs to control its mobility for vaccine design.