IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity
D. Das Gupta, C. Paul, N. Samel, M. Bieringer, D. Staudenraus, F. Marini, H. Raifer, L. Menke, L. Hansal, B. Camara, E. Roth, P. Daum, M. Wanzel, M. Mernberger, A. Nist, , M. Lohoff
This study shows IRF4 deficiency leads to B cell leukemia via Jak3 mutations that increase IL-7 sensitivity, and JAK inhibition improves survival in a mouse model.
bioRxiv · Feb 16, 2022 · PreprintCancer Biology