F. Marini

Switch-Like Phosphorylation of WRN Integrates End-Resection with RAD51 Metabolism at Collapsed Replication Forks

This study identifies phosphorylation events on WRN that regulate end-resection and RAD51-mediated repair at replication forks.

Impact of long-term storage on mid-infrared spectral patterns of serum and synovial fluid samples of dogs with osteoarthritis

This study evaluates how long-term storage affects mid-infrared spectral patterns of serum and synovial fluid from dogs with osteoarthritis, finding minimal impact on predictive model performance.

Development of a Novel Air-Liquid Interface Airway Tissue Equivalent Model for In Vitro Respiratory Modeling Studies

This study develops a 3D airway tissue equivalent model with native fibroblasts, solubilized ECM, and tunable hydrogel to better mimic human airway biology and assess its impact on epithelial differentiation.

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

An Atlas of Cells in the Human Tonsil

The paper creates a comprehensive cell atlas of the human tonsil using single-cell multi-omics data, identifying 121 cell types and uncovering regulatory mechanisms and disease-related changes.

IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

This study shows IRF4 deficiency leads to B cell leukemia via Jak3 mutations that increase IL-7 sensitivity, and JAK inhibition improves survival in a mouse model.