Cancer BiologybioRxivPreprint
Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis
M. N. Stillger, C.-Y. Chen, Z. W. Lai…·O. Schilling
This study shows that calpain-2 expression in glioblastoma cells reduces TMZ-induced DNA damage and p53-dependent apoptosis, leading to chemoresistance.
DOI 10.1101/2022.10.19.511526