Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells
M. A. Missinato, S. A. Murphy, M. Lynott, A. Kervadec, M. S. Yu, Y.-L. Chang, S. Kannan, M. Loreti, C. Lee, P. Amatya, H. Tanaka, C.-T. Huang, P. L. Puri, C. Kwon, P. D. Adams, , A. R. Colas
This study identifies four conserved transcription factors that oppose cell fate reprogramming by controlling chromatin accessibility and gene expression, and shows their potential as therapeutic targets for regenerative medicine.
bioRxiv · Jun 28, 2021 · PreprintCell Biology