Author

C.-T. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Terskikh· 3 shared C. Farhy· 2 shared A. Amador-Arjona· 1 shared A. Kervadec· 1 shared A. R. Colas· 1 shared A. Sacco· 1 shared C. Forsberg· 1 shared C. Kwon· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

A. Terskikh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Allosteric inhibitors of Zika virus NS2B-NS3 protease targeting protease in super-open conformation

I. Meewan, S. Shiryaev, C.-T. Huang, Y.-W. Lin, C.-H. Chuang, A. Terskikh, R. Abagyan

The paper identifies six allosteric inhibitors of ZIKV NS2B-NS3 protease targeting a super-open conformation pocket, showing low micromolar inhibition and antiviral activity.

bioRxiv · Mar 9, 2022Pharmacology & Toxicology

Canonical BMP2/4 signaling degrades SOX2 in glioblastoma propagating cells.

F. Comadamore, A. Amador-Arjona, C. Farhy, C.-T. Huang, H. Kornblum, A. Terskikh

This study shows BMP2/4 induces SOX2 degradation in glioblastoma propagating cells, leading to differentiation into glial cells and reduced proliferation.

bioRxiv · Feb 3, 2022 · PreprintCancer Biology

Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells

M. A. Missinato, S. A. Murphy, M. Lynott, A. Kervadec, M. S. Yu, Y.-L. Chang, S. Kannan, M. Loreti, C. Lee, P. Amatya, H. Tanaka, C.-T. Huang, P. L. Puri, C. Kwon, P. D. Adams, , A. R. Colas

This study identifies four conserved transcription factors that oppose cell fate reprogramming by controlling chromatin accessibility and gene expression, and shows their potential as therapeutic targets for regenerative medicine.

bioRxiv · Jun 28, 2021 · PreprintCell Biology

Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides

M. N. Fukuda, M. Nonaka, H. Mabashi-Asazuma, D. L. Jarvis, K. Yamasaki, T. Akama, M. Nagaoka, T. Sasai, I. Kimura-Takagi, Y. Suwa, T. Yaegashi, C.-T. Huang, C. Nishizawa-Harada

The paper develops an orally-administrable therapeutic using annexin A1-binding D-peptides to target tumor vasculature, showing suppression of brain tumor growth in mice.

PLOS ONE · Jan 6, 2021Peer-reviewedPharmacology & Toxicology

Improving drug discovery using image-based multiparametric analysis of epigenetic landscape.

C. Farhy, S. Hariharan, J. Ylanko, L. Orozco, F.-Y. Zeng, I. Pass, F. Ugarte, C. Forsberg, C.-T. Huang, D. Andrews, A. Terskikh

This paper introduces MIEL, an image-based method for epigenetic drug screening, showing it can detect active compounds, classify functions, and predict novel drug effects with higher resolution than traditional methods.

bioRxiv · May 15, 2019Cell Biology