Author

M. M. Lacle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A.-M. Baker· 2 shared C. Kimberley· 2 shared K. Smith· 2 shared A. Antoniou· 1 shared A. Banerjee· 1 shared A. M. Berner· 1 shared A. Melcher· 1 shared B. Chain· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

A.-M. Baker

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

FUME-TCRseq: Sensitive and accurate sequencing of the T-cell receptor from limited input of degraded RNA

A.-M. Baker, G. Nageswaran, P. Nenclares, T. Ronel, K. Smith, C. Kimberley, M. M. Lacle, S. Bhide, K. J. Harrington, A. Melcher, M. Rodriguez-Justo, B. Chain, T. A. Graham

FUME-TCRseq is a sensitive and accurate method for TCR sequencing from low-quality RNA, outperforming existing methods in detecting clonotypes and enabling analysis of archival tissue samples.

bioRxiv · Apr 24, 2023 · PreprintImmunology

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

W. Cross, S. Nowinski, G. Cresswell, M. Mossner, A. Banerjee, B. Lu, M. Williams, G. Vlachogiannis, L. Gay, A.-M. Baker, C. Kimberley, F. Whiting, H. Belnoue-Davis, P. Martinez, M. Traki, , Wat

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

bioRxiv · Mar 26, 2020 · PreprintCancer Biology