A. Banerjee

Structure-function relationship of PE11 esterase of Mycobacterium tuberculosis with respect to its role in virulence

This study characterizes the structure and function of PE11 esterase from Mycobacterium tuberculosis, showing its role in virulence and potential as a therapeutic target.

BUTYRATE AMELIORATES INFLAMMATION IN COLON BIOPSY SAMPLES OF IBD PATIENTS AND EXPERIMENTAL COLITIS IN MICE INVOLVING RNA BINDING PROTEIN, AUF1-IL-27 AXIS AND ACCELERATING B1a TO B10 POLARIZATION

This paper shows butyrate enhances B10 cell generation via the AUF1-IL-27 axis in IBD patients and mice, reducing inflammation.

Proteomic analysis of gut in Labeo rohita reveals ECM as Key Player in host's Response to Aeromonas hydrophila Infection

This study identifies ECM proteins as key players in Labeo rohita's immune response to Aeromonas hydrophila infection through proteomic analysis of gut tissue.

Comprehensive epitope mutational scan database enables accurate T cell receptor cross-reactivity prediction

The paper introduces a database of TCR-peptide mutational assays and a Bayesian model to predict TCR cross-reactivity, showing improved performance over existing methods.

Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models

This study shows that genetic knockout of fluoride export proteins in pathogenic oral microbes reduces their fitness in biofilms, altering microbial composition and pathogenic properties.

Bacterial pore-forming toxin pneumolysin drives pathogenicity through shed toxin-loaded host extracellular vesicles

This study shows that pneumolysin-loaded host extracellular vesicles contribute to pneumococcal pathogenesis by inducing cytotoxicity and inflammation.

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain

This study determines cryo-EM structures of SARS-CoV-2 NiRAN domain catalytic intermediates, revealing structural mechanisms for NMPylation and deRNAylation/capping, and explaining substrate preference for capping.

Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B

This study evolves two clade II Candida auris isolates to develop amphotericin B resistance, revealing distinct mechanisms and intra-clade heterogeneity in resistance acquisition.

Gestures Of Hunger: Uncovering Intentional Gestural Communication In Free-Ranging Hanuman Langurs

This study identifies intentional gestural communication in Hanuman langurs, showing they use learned gestures to request food from humans and adapt this behavior as a foraging strategy.

Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients.

Trans-omics analysis of longitudinal plasma samples from severely injured patients identifies endotypes and trajectories that predict clinical outcomes.

A host AAA-ATPase exhibits bacteriolytic activity for clearance of microbial infection

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.

Neuropathic pain has sex-specific effects on oxycodone seeking and drug-seeking ensembles in the dorsomedial prefrontal cortex

This study investigates how chronic pain affects oxycodone seeking behavior and neuronal activity in the dorsomedial prefrontal cortex, finding sex-specific differences in these effects.

Formation of clathrin-pits and ATP-independent cholesterol-dependent tubules initiates mechano-regulation on de-adhesion.

This study shows that during de-adhesion, cells use endocytosis to regulate membrane fluctuations, with dynamin-dependent and cholesterol-dependent ATP-independent mechanisms contributing.

Characterization of extracellular vesicles isolated from Sorghum bicolor reveals a conservation between monocot and eudicot extracellular vesicle proteomes

This study isolates and characterizes extracellular vesicles from Sorghum bicolor, showing partial conservation of EV proteomes with Arabidopsis.

Methotrimeprazine exerts antiviral and neuroprotective effects in Japanese encephalitis virus infection through activation of adaptive ER stress and autophagy

This study identifies Methotrimeprazine as a drug that reduces JEV infection through autophagy and ER stress, with neuroprotective and antiviral effects in a mouse model.

Left or right: Handedness in free-ranging Hanuman langurs (Semnopithecus entellus) residing in an urban ecosystem.

This study examines handedness in free-ranging Hanuman langurs, finding a left-hand bias in adults, challenging the Postural Origin Theory.

A general computational design strategy for stabilizing viral class I fusion proteins

This paper presents a computational strategy to stabilize viral class I fusion proteins by designing mutations that favor the prefusion state over the postfusion state, validated through structural and immunological testing.

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

A universal stress protein is essential for the survival of Mycobacterium tuberculosis

This study identifies Rv1636 as an essential cAMP-binding protein in Mycobacterium tuberculosis that regulates intracellular cAMP levels and is required for bacterial survival.

Quantification of differential toxin expressions and their relation to distinct lifespans of bacterial subpopulations associated with diverse host immune mechanisms

This study quantifies differential toxin expression in bacterial subpopulations and links it to their intracellular lifespans and host immune interactions.

Single-Molecule Analysis of DNA Base-Stacking Energetics Using Patterned DNA Nanostructures

This study measures single-molecule dinucleotide base-stacking energies using DNA-PAINT and designer nanostructures, revealing stabilization effects and energy ranges for specific base pairs.

Genome-wide analysis of PTR/POT transporters in Candida species and their functional characterization in the newly emerged pathogen Candida auris

The paper identifies and characterizes PTR transporters in five Candida species, finding two distinct classes and showing their role in di-/tripeptide uptake and drug resistance in C. auris.

Structural basis for ultrapotent neutralization of human metapneumovirus

This study identifies a potent monoclonal antibody against hMPV and determines its structure, revealing a novel epitope for therapeutic development.

Genomic landscape of the DHA1 family in the newly emerged pathogen Candida auris and mapping substrate repertoire of the prominent member CauMdr1

This study maps the DHA1 family in Candida auris and identifies substrates of CauMdr1, showing overexpression increases antifungal resistance.

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

Genomic and transcriptomic characterization of Delta SARS-CoV-2 infection in free-ranging white-tailed deer (Odocoileus virginianus)

The paper characterizes Delta SARS-CoV-2 infection in white-tailed deer using genomic and transcriptomic analyses, identifying mutations and host immune responses.

Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, beta, delta, and omicron variants

The paper assesses neutralizing antibody responses of convalescent and vaccinated sera against SARS-CoV-2 ancestral, beta, delta, and omicron variants.

RG203KR mutations in SARS-CoV-2 Nucleocapsid: Assessing the impact using Virus-like particle model system

The paper assesses the impact of RG203KR mutation in SARS-CoV-2 nucleocapsid using virus-like particles, showing enhanced immune responses and neutralization.

A novel innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins

The paper identifies a novel innate pathogen sensing strategy through ubiquitination of bacterial surface proteins, revealing a conserved mechanism for pathogen detection and clearance.

BubR1 recruitment to the kinetochore via Bub1 enhances Spindle Assembly Checkpoint signaling

This study shows that Bub1-mediated BubR1 recruitment to kinetochores enhances SAC signaling and reveals BubR1's dual role in SAC activation and silencing.