Author

M. M. Welch

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Biochemistry· 1

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

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A. Yildiz· 1 shared B. P. Kleinstiver· 1 shared J. A. Doudna· 1 shared J. K. Joung· 1 shared J. S. Chen· 1 shared L. B. Harrington· 1 shared S. H. Sternberg· 1 shared Y. S. Dagdas· 1 shared

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1 shared paperBiochemistry

A. Yildiz

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1 paper

Recent·Most cited

BiochemistrybioRxivAug 12, 2017

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

J. S. Chen, Y. S. Dagdas, B. P. Kleinstiver…·J. A. Doudna

This study identifies a mechanism by which CRISPR-Cas9 variants discriminate target mismatches and introduces a hyper-accurate variant with improved specificity.

DOI 10.1038/nature24268

humanexperimental assay

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