Author

L. B. Harrington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

J. A. Doudna· 2 shared J. S. Chen· 2 shared A. Yildiz· 1 shared B. P. Kleinstiver· 1 shared E. Ma· 1 shared J. K. Joung· 1 shared M. M. Welch· 1 shared S. H. Sternberg· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

J. A. Doudna

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Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivNov 29, 2017

CRISPR-Cas12a target binding unleashes single-stranded DNase activity

J. S. Chen, E. Ma, L. B. Harrington…·J. A. Doudna

This study shows that CRISPR-Cas12a activates non-specific single-stranded DNA cleavage upon guide RNA-dependent DNA binding, distinguishing it from CRISPR-Cas9.

DOI 10.1126/science.aar6245

DNA methylationexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivAug 12, 2017

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

J. S. Chen, Y. S. Dagdas, B. P. Kleinstiver…·J. A. Doudna

This study identifies a mechanism by which CRISPR-Cas9 variants discriminate target mismatches and introduces a hyper-accurate variant with improved specificity.

DOI 10.1038/nature24268

humanexperimental assay

𝕏 PostBluesky