Kingdom-specific lipid unsaturation shapes up sequence evolution in membrane arm subunits of eukaryotic respiratory complexes
P. Gupta, S. Chakroborty, A. K. Rathod, S. Bhat, S. Ghosh, P. Rao T., R. Nagaraj, M. Manna, S. Raychaudhuri
The paper investigates how lipid-protein interactions constrain sequence evolution in membrane subunits of eukaryotic respiratory complexes, finding that lipid-exposed surfaces show non-PPI disease mutations and kingdom-specific lipid unsaturation affects stability.
bioRxiv · Jul 1, 2024 · PreprintCell Biology