S. Bhat

Kingdom-specific lipid unsaturation shapes up sequence evolution in membrane arm subunits of eukaryotic respiratory complexes

The paper investigates how lipid-protein interactions constrain sequence evolution in membrane subunits of eukaryotic respiratory complexes, finding that lipid-exposed surfaces show non-PPI disease mutations and kingdom-specific lipid unsaturation affects stability.

KCNG4 genetic variant linked to migraine prevents expression of KCNB1

The paper investigates a genetic variant of KCNG4 linked to migraine and shows it prevents KCNB1 expression, suggesting a mechanism involving Kv2.1 currents in the trigeminal system.

An explainable machine learning data analytics method using TIGIT-linked genes for identifying biomarker signatures to clinical outcomes.

The paper develops an explainable machine learning model using TIGIT-linked genes to predict survival outcomes in breast cancer patients.

Investigation of H9N2 avian influenza immune escape mutant that lacks haemagglutination activity

This paper identifies an H9N2 avian influenza virus mutant with a G149E mutation in HA that loses haemagglutination activity but retains replication fitness, highlighting challenges for vaccine and surveillance efforts.

Hydrogel-Polyurethane Fiber Composites With Enhanced Microarchitectural Control For Heart Valve Replacement

This paper develops a hydrogel-polyurethane fiber composite for heart valve replacement, showing reduced platelet and bacterial attachment and calcification compared to pericardium, with promising hemodynamic performance.

Cooperative activities of dICA69 N-BAR and dCIP4 F-BAR domain proteins regulate membrane tubule organization in vivo

This study shows that dICA69 N-BAR and dCIP4 F-BAR domains cooperate to regulate membrane tubule organization in vivo through coordinated recruitment and redistribution.

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

This paper designs short, target-binding linear peptides using a contrastive learning framework, demonstrating effective binding and degradation of conformationally diverse proteins.

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

Risk Assessment of the newly emerged H7N9 avian influenza viruses

This study assesses the zoonotic risk of recent H7N9 avian influenza viruses by analyzing their receptor binding, stability, and immune escape properties compared to earlier strains.

Antigenic characterisation of human monoclonal antibodies for therapeutic use against H7N9 avian influenza virus

This study characterizes human monoclonal antibodies against H7N9 avian influenza virus, identifies key epitopes, and evaluates escape mutants' impact on viral fitness and immune evasion.

The origin of internal genes contributes to the replication and transmission fitness of H7N9 avian influenza virus

This study shows that internal gene segments from different H9N2 lineages affect the replication and transmission fitness of H7N9 avian influenza viruses in chickens and their zoonotic potential.

A mechanism of uncompetitive inhibition of the serotonin transporter

This paper identifies ECSI#6 as an uncompetitive inhibitor of the serotonin transporter, showing it preferentially binds to the K+-bound inward-facing conformation and acts as a pharmacochaperone for misfolded variants.

Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and enhanced zoonotic potential

Handling of intracellular K + determines voltage dependence of plasmalemmal monoamine transporter function

The paper investigates how intracellular K+ handling affects voltage dependence of monoamine transporter function, finding differences between DAT/NET and SERT.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

A tropane-based ibogaine analog rescues folding-deficient SERT and DAT

The paper identifies a tropane-based ibogaine analog that rescues folding-deficient SERT and DAT mutants in vitro and in vivo.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

This study shows SARS-CoV-2 Spike protein can bind to ACE2 receptors from multiple mammals, indicating broad host tropism and potential for zoonotic transmission.

Boreal marine fauna from the Barents Sea diperse to Arctic Northeast Greenland

The paper shows boreal marine species in Northeast Greenland originated from the Barents Sea, suggesting advection through Fram Strait drives Arctic colonization.