Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
C. Morel, E. Lemerle, F.-C. Tsai, T. Obadia, N. Srivastava, M. Marechal, A. Salles, M. Albert, C. Stefani, Y. Benito, F. Vandenesch, C. Lamaze, S. Vassilopoulos, M. Piel, P. Bassereau, , E. Lemichez
This study shows caveolin-1 reduces TEM tunnel size by stiffening the membrane, and its depletion increases TEM number and size, leading to higher lethality in mice during infection.
bioRxiv · Sep 27, 2022Biophysics