M. Albert

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

The paper develops a microfluidic platform to screen compounds that reduce bacterial phenotypic variation and enhance tuberculosis drug efficacy.

ISG15 is required for the dissemination of Vaccinia virus extracellular virions

This paper shows that ISG15 regulates Vaccinia virus dissemination by affecting extracellular virion production and actin tail formation.

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

This study shows caveolin-1 reduces TEM tunnel size by stiffening the membrane, and its depletion increases TEM number and size, leading to higher lethality in mice during infection.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer's Disease

This study measures amygdala and ERC atrophy rates in preclinical Alzheimer's disease using MRI and reconstructs 3D tau pathology distributions, finding amygdala atrophy comparable to ERC and suggesting it as a potential biomarker.

Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer's Disease

The paper aligns 2D histology images of AD pathology with 3D MRI to reconstruct NFT density in the MTL, finding high NFT density in the rostral hippocampus and adjacent regions.

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

This study shows that QPCTL inhibition reduces monocyte migration and alters myeloid cell infiltration, enhancing anti-tumor immunity when combined with anti-PD-L1 therapy.

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice.

This study develops a mouse-adapted SARS-CoV-2 strain that replicates efficiently in standard mice and causes mild to moderate lung disease.

Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission

The paper shows that SARS-CoV-2 variants with the N501Y mutation can infect and transmit to mice, suggesting potential for rodent reservoirs.

Genotyping-by-sequencing-based identification of Arabidopsis pattern recognition receptor RLP32 recognizing proteobacterial translation initiation factor IF1

The paper identifies RLP32 as the Arabidopsis receptor for the bacterial pattern IF1, revealing its role in PTI and resistance to Pseudomonas syringae.

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

This study assesses the neutralization sensitivity of SARS-CoV-2 B.1.1.7 and B.1.351 variants compared to D614G using sera and nasal swabs, finding reduced efficacy against B.1.351 in some convalescent and vaccinated individuals.

Convergent evolution of distinct immune sensor systems for fungal polygalacturonases in Brassicaceae

Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation

This study identifies aquaporin-3 as a regulator of endosome-to-cytosol transfer by facilitating hydrogen peroxide entry, which induces lipid peroxidation and antigen release.

A flagellate-to-amoeboid switch in the closest living relatives of animals

This study shows that choanoflagellates can switch from a flagellate to an amoeboid phenotype under spatial confinement, suggesting myosin-mediated amoeboid motility was present in the last common ancestor of animals and choanoflagellates.

Sex differences in IL-17 determine chronicity in male versus female urinary tract infection

The paper investigates sex differences in urinary tract infection (UTI) severity, finding that male mice develop chronic infections due to impaired innate immunity, while females exhibit robust IL-17-driven responses that promote bacterial clearance.