P. Bassereau

Membrane curvature association of amphipathic helix 8 drives constitutive GPCR endocytosis

The paper identifies amphipathic helix 8 as a driver of constitutive GPCR endocytosis through membrane curvature association.

STRIPAK controls cell-cell communication by promoting cytoneme biogenesis through the membrane-sculpting function of Slik.

This study identifies STRIPAK's role in promoting cytoneme biogenesis through Slik's membrane-sculpting function, which drives cell proliferation in Drosophila.

Conformational changes of the ABC Transporter BmrA Depend on Membrane Curvature

This study shows that the conformational changes of the bacterial ABC transporter BmrA are influenced by membrane curvature, affecting its activity and conformational states.

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

This study shows caveolin-1 reduces TEM tunnel size by stiffening the membrane, and its depletion increases TEM number and size, leading to higher lethality in mice during infection.

Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction

The paper shows that cells spread on fluid lipid bilayers coated with Invasin, relying on microtubule-mediated forces rather than actomyosin contraction.

A balance between actin and Eps8/IRSp53 utilization in branched versus linear actin networks determines tunneling nanotube formation

This study identifies how the balance between branched and linear actin network formation, mediated by Eps8 and IRSp53, determines tunneling nanotube (TNT) formation.

Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage

This study presents cryo-EM structures of CHMP2A-CHMP3 ESCRT-III filaments and shows they constrict and cleave membrane tubes through electrostatic interactions and VPS4-mediated remodeling.

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation

This study shows BIN1 is required for filopodia formation by bundling actin and recruiting dynamin and ezrin, dependent on IRSp53 and membrane curvature.

Activated I-BAR IRSp53 clustering controls the formation of VASP-actin-based membrane protrusions

The paper investigates how IRSp53 clustering regulates filopodia initiation by recruiting VASP to form actin-based membrane protrusions.

Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1

This study shows that CHMP1B and IST1 can sever membranes through a friction-driven mechanism, requiring constriction and extensional force, but not VPS4 or spastin.

PI4P and BLOC-1 remodel endosomal membranes into tubules

This study shows how PI4P and BLOC-1 coordinate to form and stabilize endosomal tubules, essential for membrane remodeling and pathogen trafficking.

Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53.

This study shows that IRSp53 assists HIV-1 in forming membrane curvature necessary for complete particle assembly.

Influence of membrane-cortex linkers on the extrusion of membrane tubes

This study investigates how membrane-cortex linkers affect membrane tube extrusion through simulations and experiments, finding non-linear force dependencies and increased stability against coalescence.

Membrane-mediated Forces Can Stabilize Tubular Assemblies of I-BAR Proteins

This study shows lipid clustering stabilizes I-BAR domain aggregates, leading to cylindrical membrane protrusions instead of bulbous ones.

Myosin 1b Flattens and Prunes Branched Actin Filaments.

This paper shows myosin 1b flattens and breaks Arp2/3-dependent actin branches and reduces new branch formation using in vitro assays and TIRF microscopy.

Human ESCRT-III Polymers Assemble on Positively Curved Membranes and Induce Helical Membrane Tube Formation

This study investigates how ESCRT-III proteins assemble on curved membranes and induce helical tube formation using in vitro experiments and imaging techniques.

A new actin depolymerase: a Myosin 1 motor

This study identifies myosin1b as a new actin depolymerase that enhances depolymerization at the barbed end through unique interactions, distinct from myosin II.

The ESCRT-III Isoforms CHMP2A And CHMP2B Display Different Effects On Membranes Upon Polymerization

This study compares the membrane interactions of CHMP2A and CHMP2B, finding they have distinct lipid binding preferences and mechanical effects on membranes.

Adhesion to nanofibers drives cell membrane remodeling through 1D wetting

This study identifies a novel physical mechanism, 1D wetting, by which Neisseria meningitidis drives plasma membrane remodeling on nanofibers independent of F-actin.

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

This study investigates how ezrin enrichment on curved membranes depends on its conformation or interaction with curvature-sensitive partners, showing that specific conformations and binding to I-BAR-domain proteins enable targeting to curved membranes.