Nanoliter-scale selection of optimized bioengineered peptide antibiotics that rescue mice with bacterial lung infection
N. Boehringer, Z. G. Wuisan, M. Marner, D. Kresna, U. Mettal, S. Schmitt, S. Reiter, Y. Liu, K. Brinkrolf, O. Rupp, O. Schwengers, J. I. Findeisen, S. Herold, U. Matt, T. F. Schaeberle
This study uses a mutasynthetic library to identify optimized darobactin derivatives that effectively treat bacterial lung infections in mice.
bioRxiv · May 30, 2024 · PreprintMicrobiology