Cancer BiologybioRxiv
A Systems Mechanism for KRAS Mutant Allele Specific Responses to Targeted Therapy
T. McFall, J. K. Diedrich, M. Mengistu…·E. C. Stites
The paper investigates why KRAS G13D mutant colorectal cancers respond to anti-EGFR therapy despite general resistance, using computational models and experimental validation.
DOI 10.1126/scisignal.aaw8288