Vibrio deploys Type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress
M. de Souza Santos, S. Chimalapati, A. Ray, W.-R. Lee, G. Rivera-Cancel, A. Lafrance, G. Vale, M. Mitsche, J. G. McDonald, J. Liou, K. Orth
This study identifies VPA0226, a lipase secreted by Vibrio parahaemolyticus, which esterifies cholesterol with host fatty acids to weaken the plasma membrane and enable bacterial egress from host cells.
bioRxiv · Nov 12, 2019Microbiology