K. Orth

Molecular Determinants for Differential Activation of the Vibrio parahaemolyticus Bile Acid Receptor

This study identifies molecular determinants for differential activation of the Vibrio parahaemolyticus bile acid receptor by showing how specific bile acids bind to the VtrA/VtrC complex and influence pathogenic gene expression.

Enzymatic Specificity of Conserved Rho GTPase Deamidases Promotes Invasion of Vibrio parahaemolyticus at the Expense of Infection

This study shows that CNF1 enhances V. parahaemolyticus invasion but fails to complete infection, while VopC allows efficient invasion and infection completion, highlighting the importance of enzymatic specificity in bacterial pathogenesis.

Fic-mediated AMPylation tempers the Unfolded Protein Response during physiological stress

This study shows that Fic-mediated AMPylation regulates the UPR response in the pancreas during stress, preventing excessive inflammation and damage.

Co-Component Signal Transduction Systems: fast-evolving virulence regulation cassettes discovered in enteric bacteria

The paper identifies fast-evolving co-component signal transduction systems in enteric bacteria using domain organization and machine learning-based fold predictions.

Transertion is used for localized expression and assembly of Vibrio parahaemolyticus T3SS2

The paper shows Vibrio parahaemolyticus uses transertion to assemble T3SS2 in response to bile acids.

Role of two metacaspases in development and pathogenicity of the Rice Blast fungus, Magnaporthe oryzae

This study identifies two metacaspases in Magnaporthe oryzae that regulate fungal growth, development, and stress responses, contributing to pathogenicity.

Manipulation of IRE1-dependent MAPK signaling by a Vibrio agonist-antagonist effector pair

This paper shows how Vibrio parahaemolyticus uses two effectors, VopQ and VopS, to manipulate host signaling by first inducing pro-survival responses and then triggering cell death.

Structures of an intact yeast V-ATPase alone and in complex with bacterial effector VopQ

This study reports cryo-EM structures of the intact yeast V-ATPase and its complex with the bacterial effector VopQ, revealing interactions and catalytic conformations.

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

The paper identifies a pathway linking calcium influx to focal adhesion turnover during cell migration through the ORP3/IQSec1 complex and Arf5 activation.

Vibrio deploys Type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

This study identifies VPA0226, a lipase secreted by Vibrio parahaemolyticus, which esterifies cholesterol with host fatty acids to weaken the plasma membrane and enable bacterial egress from host cells.

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

This study determines high-resolution cryo-EM structures of E. coli hemolysin ClyA oligomers, revealing new oligomeric states and mechanistic insights into pore assembly.

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

This study shows that VopL, a T3SS2 effector of Vibrio parahaemolyticus, inhibits host ROS production by disrupting actin cytoskeleton function, thereby promoting bacterial intracellular survival.