Author

G. Vale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Ecology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:C. elegans· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. G. McDonald· 4 shared B. Wang· 2 shared C. Wang· 2 shared D. K. Ma· 2 shared H. Deng· 2 shared H. Hariri· 2 shared J. Bowerman· 2 shared K. Eckert· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCell Biology

J. G. McDonald

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Author profile →

6 papers

Recent·Most cited

A megaprotein brake for aging and insulin-mTOR signaling

T. Pandey, B. Wang, C. Wang, J. Zu, H. Deng, K. Shen, G. Vale, J. G. McDonald, D. K. Ma

This study identifies LPD-3 as a megaprotein that regulates insulin-mTOR signaling and aging in C. elegans by modulating sphingolipid and insulin pathways.

bioRxiv · Feb 14, 2023 · PreprintPhysiology

A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

C. Wang, B. Wang, T. Pandey, Y. Long, J. Zhang, F. Oh, J. Sima, R. Guo, Y. K. Liu, C. Zhang, S. Mukherjee, M. C. Bassik, W. Lin, H. Deng, G. Vale, , D. K. Ma

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

bioRxiv · Aug 25, 2022 · PreprintCell Biology

Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease

S. Datta, J. Bowerman, H. Hariri, R. Ugrankar, K. Eckert, C. Corley, G. Vale, J. G. McDonald, M. M. Henne

This study identifies Snx14's role in maintaining lipid saturation and ER homeostasis, showing its deficiency leads to lipotoxicity and contributes to SCAR20 disease.

bioRxiv · May 31, 2020Cell Biology

Assessing the effect of insecticide-treated cattle on tsetse abundance and trypanosome transmission at the wildlife-livestock interface in Serengeti, Tanzania

J. S. Lord, R. S. Lea, F. Allan, M. Byamungu, D. Hall, J. Lingley, F. Mramba, E. Paxton, G. Vale, J. Hargrove, L. Morrison, S. Torr, H. Auty

This study assesses the impact of farmer-led insecticide-treated cattle on tsetse fly abundance and trypanosome transmission at the wildlife-livestock interface in Serengeti, Tanzania, finding increased tsetse mortality and reduced trypanosome prevalence.

bioRxiv · Apr 14, 2020Ecology

Vibrio deploys Type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

M. de Souza Santos, S. Chimalapati, A. Ray, W.-R. Lee, G. Rivera-Cancel, A. Lafrance, G. Vale, M. Mitsche, J. G. McDonald, J. Liou, K. Orth

This study identifies VPA0226, a lipase secreted by Vibrio parahaemolyticus, which esterifies cholesterol with host fatty acids to weaken the plasma membrane and enable bacterial egress from host cells.

bioRxiv · Nov 12, 2019Microbiology

Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

R. Ugrankar, J. Bowerman, H. Hariri, M. Chandra, K. Chen, M.-F. Bossanyi, S. Datta, S. Rogers, K. Eckert, G. Vale, A. Victoria, J. Fresquez, J. McDonald, S. Jean, B. Collins, M. Henne

This study identifies Snazarus as a regulator of lipid droplet organization in Drosophila adipocytes, showing its role in maintaining peripheral lipid droplets at plasma membrane contacts.

bioRxiv · Apr 26, 2019Cell Biology