J. G. McDonald

This study identifies LPD-3 as a megaprotein that regulates insulin-mTOR signaling and aging in C. elegans by modulating sphingolipid and insulin pathways.

This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

This study identifies Snx14's role in maintaining lipid saturation and ER homeostasis, showing its deficiency leads to lipotoxicity and contributes to SCAR20 disease.

This study identifies VPA0226, a lipase secreted by Vibrio parahaemolyticus, which esterifies cholesterol with host fatty acids to weaken the plasma membrane and enable bacterial egress from host cells.

This study shows that desmosterol and its mimetics selectively activate LXR in macrophages without inducing SREBP1c-mediated hypertriglyceridemia, unlike conventional LXR agonists.