M. Morck

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

This study examines how mutations in different regions of the β-cardiac myosin lever arm affect motor function and autoinhibition, revealing divergent effects based on mutation location.

Mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin

The paper shows that mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin, linking mutations to cardiomyopathy mechanisms.