H. Gong

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

The paper uses optical tweezers and Brillouin microscopy to study brain mechanical properties in larval zebrafish, showing macrophages influence tissue mechanics during development.

TopoDiff improves protein backbone generation by using a topology-aware latent encoding to enhance controllability and coverage of generated structures.

This study investigates how YAP-mediated mechanogenotypes influence mechanical adaptation of cancer cells during extravasation and organ colonization in vivo.

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

This paper shows that mavacamten stabilizes myosin in off states, which can still be recruited by physiological inotropic effectors to maintain cardiac function.

This study identifies three PRC barrel proteins in Haloferax volcanii essential for archaeal cell division, showing their conservation and role in division across haloarchaea.

This study identifies contractile deficits in right ventricular myocytes of HFrEF-PH patients, showing reduced calcium-activated tension and altered myosin ATP turnover, with implications for targeted therapies.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This paper uses phylogenetic analysis to trace the origins of monkeypox viruses and their 2022 circulating strains, identifying possible origins from cowpox viruses and two lineages linked to 2021 exported strains.

This study uses X-ray diffraction to compare thick filament activation dynamics in fast and slow-twitch rat muscles, finding distinct structural transitions that may explain their differing contraction properties.

This study shows that mice fed a high starch diet become obese but remain insulin sensitive, unlike those on a high fat diet, with differences in ceramide levels and lipogenesis contributing to this effect.

The paper presents an integrated optical chip for structured illumination microscopy, enabling high-resolution imaging by generating a hexagonal illumination pattern without alignment.

This study examines the scaling of spiracles in scarab beetles, finding that diffusive capacities scale isometrically but require higher oxygen gradients in larger species, while advective capacities match respiratory demands during activity.

This study shows that cardiac myosin filaments are directly regulated by calcium, transitioning from inactive to active states through structural changes.

This paper introduces a method to quantify myofibrillar orientation in cardiac muscle and shows it detects greater disorientation in diseased tissue compared to healthy controls.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This paper develops FLT4-targeted nanocarriers for glaucoma therapy, showing improved IOP reduction and targeted delivery to Schlemms canal cells.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

The paper identifies mutations in FtsW and FtsI that reveal the activation mechanism of the SEDS-bPBP complex FtsWI, showing it relies on an interaction between FtsW's ECL4 and FtsI's pedestal domain.

This study identifies TRPM4 as a key regulator of pressure overload-induced cardiac hypertrophy by modulating CaMKII{delta}-HDAC4-MEF2A and calcineurin-NFAT-GATA4 pathways in mice.

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

This study evaluates the therapeutic effects of IL12IL2GMCSF fusion protein in canine tumors, showing significant response rates with minimal adverse effects.

This study examines the effects of dietary Citrus reticulata 'Chachi' products on the fecal microbiome of weaned piglets using multi-omics analyses, showing changes in microbial diversity, SCFAs, and proteomic profiles.

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This study identifies ACE2-expressing cells in the digestive system using single-cell transcriptomes, suggesting the digestive tract as a potential route for 2019-nCov infection.

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.

This study shows that TLR3 deficiency in human oviduct epithelial cells alters immune responses to Chlamydia trachomatis infection, increasing inflammation and pathogenesis markers.

This study shows that TLR3 deficiency worsens epithelial barrier loss in genital tract Chlamydia muridarum infection, as measured by transepithelial resistance and tight-junction gene expression.