Author

F. L. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:proteomics· 1

Frequent Co-Authors

B. A. Colson· 1 shared C. S. Rogers· 1 shared D. V. Trivedi· 1 shared E. M. Green· 1 shared H. Gong· 1 shared J. A. Spudich· 1 shared J. G. Seidman· 1 shared K. M. Ruppel· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

B. A. Colson

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2 papers

Recent·Most cited

N-terminal cardiac myosin-binding protein C interactions with myosin and actin filaments using time-resolved FRET

F. L. Wong, T. A. Bunch, V. C. Lepak, B. A. Colson

This study uses TR-FRET to analyze cMyBP-C interactions with myosin and actin, revealing phosphorylation and mutation effects on binding, with implications for HCM therapy.

bioRxiv · Sep 7, 2022 · PreprintBiophysics

Mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin

R. L. Anderson, D. V. Trivedi, S. S. Sarkar, M. Henze, W. Ma, H. Gong, C. S. Rogers, F. L. Wong, M. Morck, J. G. Seidman, K. M. Ruppel, T. C. Irving, R. Cooke, E. M. Green, J. A. Spudich

The paper shows that mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin, linking mutations to cardiomyopathy mechanisms.

bioRxiv · Mar 10, 2018Biochemistry