Coupling of NOD2 to GIV is Required for Bacterial Sensing
G. D. Katkar, M. S. Anandachar, S. Sinha, S.-R. Ibeawuchi, C. R. Espinoza, J. Coates, Y. S. Malhotra, M. Mullick, V. Castillo, D. T. Vo, D. Sahoo, P. Ghosh
This paper identifies GIV as a NOD2-interactor that enhances bacterial sensing and signaling in macrophages, revealing how loss of function in the NOD2 1007fs variant impairs protective immune responses.
bioRxiv · Apr 26, 2022 · PreprintImmunology