Author

V. Castillo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

P. Ghosh· 6 shared C. R. Espinoza· 4 shared D. Sahoo· 4 shared G. D. Katkar· 4 shared C. Tindle· 3 shared S. Das· 3 shared S. Sinha· 3 shared S. Taheri· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersImmunology

P. Ghosh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Machine Learning Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers

S. Sinha, J. Alcantara, K. Perry, V. Castillo, A. Ondersma, S. Banerjee, E. McLaren, C. R. Espinoza, S. Taheri, E. Vidales, C. Tindle, A. Adel, S. Amirfakhri, J. R. Sawires, J. Yang, , P. Ghosh

This paper introduces a machine learning framework to identify and target transcriptomic vulnerabilities in colorectal cancer, demonstrating that differentiation therapy selectively eliminates cancer stem cells and reduces recurrence risk.

bioRxiv · Sep 13, 2023 · PreprintCancer Biology

Coupling of NOD2 to GIV is Required for Bacterial Sensing

G. D. Katkar, M. S. Anandachar, S. Sinha, S.-R. Ibeawuchi, C. R. Espinoza, J. Coates, Y. S. Malhotra, M. Mullick, V. Castillo, D. T. Vo, D. Sahoo, P. Ghosh

This paper identifies GIV as a NOD2-interactor that enhances bacterial sensing and signaling in macrophages, revealing how loss of function in the NOD2 1007fs variant impairs protective immune responses.

bioRxiv · Apr 26, 2022 · PreprintImmunology

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

S. Sinha, V. Castillo, C. R. Espinoza, C. Tindle, A. G. Fonseca, J. M. Dan, G. D. Katkar, S. Das, D. Sahoo, P. Ghosh

This study identifies shared cellular and molecular features between severe COVID-19 and idiopathic pulmonary fibrosis, highlighting ER stress and AT2 cell dysfunction as key drivers.

bioRxiv · Nov 28, 2021Immunology

GIV/Girdin, a Non-receptor Modulator for Gαi/s, Regulates Spatiotemporal Signaling during Sperm Capacitation and is Required for Male Fertility

S. Reynoso, V. Castillo, G. D. Katkar, I. Lopez-Sanchez, S. Taheri, C. R. Espinoza, C. Rohena, D. Sahoo, P. Gagneux, P. Ghosh

This study shows GIV/Girdin regulates spatiotemporal signaling during sperm capacitation and is essential for male fertility by modulating distinct signaling programs in sperm tail and head.

bioRxiv · May 6, 2021Cell Biology

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19

C. Tindle, M. Fuller, A. Fonseca, S. Taheri, S.-R. Ibeawuchi, N. Beutler, G. Katkar, A. Claire, V. Castillo, M. Hernandez, H. Russo, J. Duran, L. E. Crotty Alexander, A. Tipps, G. Lin, , S. Das

This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.

bioRxiv · Oct 17, 2020Cell Biology

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

L. A. B. Swanson, G. D. Katkar, J. Tam, R. Pranadinata, Y. Chareddy, J. E. Coates, M. S. Amandachar, V. Castillo, J. Olson, V. Nizet, I. Kufareva, S. Das, P. Ghosh

This study shows GIV/Girdin dampens TLR4-mediated inflammatory responses in macrophages by inhibiting receptor dimerization and downstream signaling.

bioRxiv · Aug 29, 2020Immunology