Delayed antigen-specific CD4+ T cell induction correlates with impaired immune responses to SARS-COV-2 mRNA vaccination in the elderly
N. Jo, Y. Hidaka, O. Kikuchi, M. Fukahori, T. Sawada, M. Aoki, M. Yamamoto, M. Nagao, S. Morita, T. E. Nakajima, M. Muto, Y. Hamazaki
The paper examines how delayed CD4+ T cell responses in the elderly correlate with reduced vaccine effectiveness and lower reactogenicity to SARS-CoV-2 mRNA vaccines.
bioRxiv · May 10, 2022 · PreprintImmunology