Author

M. Aoki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H. Ehara· 2 shared M. Goto· 2 shared N. Suzuki· 2 shared S.-i. Sekine· 2 shared Y. Murayama· 2 shared A. Sakamot· 1 shared E. Mori· 1 shared E. Nitta· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

H. Ehara

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex

T. Yanagisawa, Y. Murayama, H. Ehara, M. Goto, M. Aoki, S.-i. Sekine

The paper reports cryo-EM structures of the Rat1-Rai1-Rtt103 complex and RNAPII complexes from yeast, revealing the mechanism of mRNA transcription termination by Rat1 exonuclease.

bioRxiv · Mar 28, 2024Biochemistry

Establishment of a novel amyotrophic lateral sclerosis patient-derived blood-brain barrier model: Investigating barrier dysfunction and immune cell interaction

K. Matsuo, K. Nagata, R. Umeda, T. Shiota, S. Morimoto, N. Suzuki, M. Aoki, H. Okano, M. Nakamori, H. Nishihara

This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.

bioRxiv · Jan 15, 2024 · PreprintCell Biology

Zinc finger domains bind low-complexity domain polymers

N. Iguchi, N. Isozumi, Y. Hattori, T. Imamura, M. So, H. Nanaura, T. Kiriyama, N. Eura, M. Yamaoka, M. Nakanishi, M. Mori, S. Ohki, H. Kumeta, H. Koga, M. Watabe, , E. Mori

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

bioRxiv · Oct 29, 2023 · PreprintBiochemistry

Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase

Y. Murayama, H. Ehara, M. Goto, M. Aoki, T. Yokoyama, S.-i. Sekine

The paper reports the cryo-EM structure of RNA polymerase engaged with Rho, revealing how Rho interacts with RNAP to mediate transcription termination.

bioRxiv · Sep 2, 2022Biochemistry

Delayed antigen-specific CD4+ T cell induction correlates with impaired immune responses to SARS-COV-2 mRNA vaccination in the elderly

N. Jo, Y. Hidaka, O. Kikuchi, M. Fukahori, T. Sawada, M. Aoki, M. Yamamoto, M. Nagao, S. Morita, T. E. Nakajima, M. Muto, Y. Hamazaki

The paper examines how delayed CD4+ T cell responses in the elderly correlate with reduced vaccine effectiveness and lower reactogenicity to SARS-CoV-2 mRNA vaccines.

bioRxiv · May 10, 2022 · PreprintImmunology

CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre

T. Imasaki, S. Kikkawa, S. Niwa, Y. Saijo-Hamano, H. Shigematsu, K. Aoyama, K. Mitsuoka, M. Aoki, A. Sakamot, Y. Tomabechi, N. Sakai, M. Shirouz, S. Taguchi, Y. Yamagish, T. Setsu, , R. Nitta

The paper shows CAMSAP2 nucleates microtubules from soluble β-tubulin without γ-tubulin, reducing the nucleation barrier and forming aster-like structures.

bioRxiv · Mar 1, 2021 · PreprintCell Biology