S. Morita

This study shows that blocking CXCR4 and PD-1 together improves dendritic cell activation and immune responses against HCC in mouse models.

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

This study shows metastasized breast cancer cells eliminate CD169+ macrophages from lymph nodes, impairing anti-cancer immunity.

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

This study uses machine learning to predict fish recruitment for Arabesque greenling, finding gradient boosting outperforms linear regression and random forest in accuracy.

This study identifies how p300/CBP reads and writes histone acetylation to propagate epigenetic marks and activate gene transcription.

The paper studies the evolution of horn length and lifting strength in Trypoxylus dichotomus, showing independent increases in horn length in Northern and Southern lineages with mechanical trade-offs and compensatory changes.

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.

This paper tests the allosteric model of TCR activation by designing a membrane ligand that inhibits TCR signaling, supporting the model and suggesting therapeutic applications.

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

The paper examines how delayed CD4+ T cell responses in the elderly correlate with reduced vaccine effectiveness and lower reactogenicity to SARS-CoV-2 mRNA vaccines.

The paper shows that LAT condensates form in response to pMHC:TCR binding events, with condensation probability linked to binding dwell time and a mutation affecting this process.

This paper investigates how the geometry of synthetic TCR agonists affects T cell activation, finding that ligand height, not epitope, determines potency.

This study shows that COA-Cl increases cardiac organoid contraction by suppressing phosphodiesterase activity, independent of S1P1R and A1R.

This study reveals how rice endosperm cells adapt to heat stress through osmotic adjustments and nitrogen-dependent changes in organelle compartments, reducing chalkiness.