Genetic determinants of antibiotic resistance and the evolution of trade-offs during adaptation in a single patient
R. J. Woods, C. Barbosa, L. Koepping, J. A. Raygoza Garay, M. Mwangi, A. F. Read
This study tracks genetic and phenotypic changes in antibiotic resistance in a single patient's infection over time, revealing no pan-resistant isolate and complex patterns of collateral sensitivity and combination therapy responses.
bioRxiv · Oct 6, 2021 · PreprintEvolutionary Biology