C. Barbosa

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

The paper demonstrates a mutation-guided vaccine strategy that induces HIV broadly neutralizing antibodies in mice by selecting for rare B cell lineage mutations.

Genetic determinants of antibiotic resistance and the evolution of trade-offs during adaptation in a single patient

This study tracks genetic and phenotypic changes in antibiotic resistance in a single patient's infection over time, revealing no pan-resistant isolate and complex patterns of collateral sensitivity and combination therapy responses.

Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation through N-formyl peptide receptor 2 in a chronic murine model of Chagas disease

This study shows that AT-RvD1 reduces cardiac inflammation and parasite load in a chronic Chagas disease model by acting through FPR2.

Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

This study compares the immunogenicity of mRNA-LNP vaccines to protein vaccines in nonhuman primates, finding comparable or superior HIV-1 antibody responses.

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients

Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats

This study compares the effects of moderate and high-intensity aerobic training on microvascular reactivity and myocardial oxidative stress in rats, finding that high intensity improves antioxidant defenses more than moderate intensity.

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

This study tests the evolutionary stability of collateral sensitivity in Pseudomonas aeruginosa, finding that resistance to one antibiotic often leads to hypersensitivity to another, but evolutionary outcomes depend on drug order.