Of Rats and Men, a Translational Model to Understand Vancomycin Pharmacokinetic/Toxicodynamic relationships
M. H. Scheetz, G. Pais, T. Lodise, S. Tong, J. Davis, J. N. O'Donnell, J. Liu, M. Neely, W. Prozialeck, P. Lamar, N. J. Rhodes, T. Holland
The paper links vancomycin toxicity data from a rat model to two human clinical studies, showing rats are more sensitive to kidney injury at therapeutic concentrations.
bioRxiv · Apr 22, 2021Pharmacology & Toxicology