Pharmacology & ToxicologybioRxiv
Of Rats and Men, a Translational Model to Understand Vancomycin Pharmacokinetic/Toxicodynamic relationships
M. H. Scheetz, G. Pais, T. Lodise…·T. Holland
The paper links vancomycin toxicity data from a rat model to two human clinical studies, showing rats are more sensitive to kidney injury at therapeutic concentrations.
DOI 10.1128/aac.01060-21